منابع مشابه
Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus
Natural product discovery efforts have focused primarily on microbial biosynthetic gene clusters (BGCs) containing large multimodular polyketide synthases and nonribosomal peptide synthetases; however, sequencing of fungal genomes has revealed a vast number of BGCs containing smaller NRPS-like genes of unknown biosynthetic function. Using comparative metabolomics, we show that a BGC in the huma...
متن کاملPresence of isoquinoline alkaloids in molluscan ganglia.
UNLABELLED Tetrahydropapaveroline and reticuline, isoquinoline alkaloids, were purified and identified in the pedal ganglia of the marine mollusk Mytilus edulis. OBJECTIVES To determine the presence of tetrahydropapaveroline and reticuline, isoquinoline alkaloids, in animal tissues previously shown to express opiate receptors. METHODS AND RESULTS This was achieved by high performance liquid...
متن کاملSynthesis of isoquinoline and yohimbinoid alkaloids
A systematic survey of the different synthetic methodologies available for the syntheses of isoquinoline and yohimbinoid alkaloids revealed that the general approaches to these compounds involved either an A/B C — D/—i E approach or a D/E — C/B/A approach% We have now devised a novel method for the syntheses of both the isoquinoline and indole alkaloids belonging to the tetra— hydroprotoberberi...
متن کاملProtoberberine isoquinoline alkaloids from Arcangelisia gusanlung.
HPLC-DAD-directed isolation and purification of the methanol extract of stems of Arcangelisia gusanlung H. S. Lo. led to the isolation of a new protoberberine alkaloid, gusanlung E (1), along with fourteen known derivatives 2-15, seven of which were obtained from the genus Arcangelisia for the first time. The structures and absolute stereochemistry of these compounds were elucidated on the basi...
متن کاملQuaternary isoquinoline alkaloids from Stephania cepharantha.
From the quaternary alkaloidal fraction of the dried tubers of Stephania cepharantha, two new isoquinoline alkaloids, stecepharine and tetradehydroreticuline have been isolated along with the known compounds, magnoflorine, menisperine, steponine, cyclanoline, oblongine, cis-N-methylcapaurine and 2'-N-methylisotetrandrine. cis-N-Methylcapaurine (=9-O-methylstecepharine) was isolated as a natural...
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ژورنال
عنوان ژورنال: Planta Medica
سال: 1979
ISSN: 0032-0943,1439-0221
DOI: 10.1055/s-0028-1097235